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Contrast, resistance to extinction, and forgetting in rats

As dose optimization continues and trial durations extend, oral agents may close the gap further

The positive effect of CoQ10 treatments is recognized in patients with heart failure and myocardial ischemia, such as the reduction of oxidative stress derived from cardiovascular causes, decrease in mortality and hospitalization and improvement in cardiac function [175, 176]

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Increase in symptoms All study participants reported an increase in symptoms at six weeks compared to when they started the study, though the increase was greater in the placebo group