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Although the addition of the membrane context greatly increases the realism of the system compared with previous membrane-free structural analyses, it is of course possible that yet further changes will be seen once it becomes feasible to reach atomistic resolution in situ and determine the structure as found on lysosomes in cells
Doose, D
Meta-analysis resulted in a SMD of 1.25 (95% CI 0.87 - 1.62) across 203 cases and 184 controls using a random effects model
However, its consistent with many of the Medifast studies, which saw huge attrition
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