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J Anal Bioanal Chem

EC wrote the first draft of the manuscript and the cardiometabolic disorders section

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There is one open-label intravenous safety pilot in two healthy adults, who received single doses of 10 mg and 20 mg with no comparator, no blinding, and short-term observation limited to vital signs, self reported symptoms and labs across two days [4]

Starting with lower doses and monitoring for adverse effects is a standard, cautious approach before adjusting upward based on clinical response