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265,266 PERK-eIF2-ATF4 signaling in angiogenesis, EMT, and metastatic progression Persistent activation of the cytoprotective arm of the UPR can actively drive tumorigenesis and malignant progression

It can also lead to more serious problems, such as heart attacks and strokes

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Firstly, substantial evidence from large CVOTs corroborates the use of GLP-1 RAs with CV benefits in patients with T2D at high risk of CV disease [34,35,36,37, 56, 79], which is also in line with the up-to-date NICE, SIGN and ADA guidelines described above