Both SP and L-car attenuated DOX-induced ovarian oxidative damage, subsequent ovarian mtDNA expression, and activation of downstream inflammatory and apoptotic pathways, particularly lowering P53 and caspase-3 protein expressions in preantral follicles, thus preventing ovarian insult and follicle demise and extending the post-chemotherapy fertile period
Medicines, 9(9), 47
Lamont AS, Roberts MS, Holdsworth DG, Atherton A, Shepherd JJ
FAO substrates are derived from the external environment via specific transporters able to mediate fatty acid uptake, such as CD36 (Figure 3)
A patient carrying favorable GLP-1R variants, for example, may theoretically benefit more from semaglutide monotherapy, potentially reducing the clinical rationale for stacking