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[2] [3] However, it is important to distinguish between direct pharmacological effects and indirect consequences of treatment
Baseline: Metformin 1000-2000mg daily, stable dose Weeks 1-4: Add Retatrutide 1mg weekly, maintain Metformin Weeks 5-8: Increase Retatrutide to 4mg weekly Weeks 9-12: Increase Retatrutide to 8mg weekly Week 12+: Assess A1C and consider Retatrutide dose increase to 12mg if needed
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"It is very difficult to isolate whether psychiatric complications in patients with obesity are associated with their distress about their weight, other life stressors, with a personal or family history of psychiatric illness, or with the effects of trying to lose weight or with having successfully lost it." Wadden told Newsweek that weight loss could result in improvements to physical health and quality of life, and so could improve mental healthbut in a small number of people, weight loss could also have a negative effect
