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United States: TB500 is not approved by the FDA and is not legally available as a prescription medication

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51,113 Based on indications for the drug industry released by the FDA in 2019, candidate drugs achieving histological outcomes can be conditionally approved, and there remains a necessity to refine the assessment of clinical outcomes in the future

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68,69 Both MTHFD2 and MTHFD1 are markedly elevated and correlated with poor survival across human cancers