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These context-dependent effects of cellular processes, transcription factors, and metabolites are present in many aspects of biology, influenced by the concomitant expression of receptors, metabolic enzymes/pathways of each cell, molecular partners, and convergent or divergent signaling/ transcription factors activation

Open questions How GSH anabolism is altered in the myocardium under pathological and physiological conditions

NRF2 coordinates with several antioxidant pathways in response to oxidative stress (Figure 2)

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