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Among participants, 86.4% achieved at least 5% body weight loss, and between 69% and 79% achieved 10% or greater loss across the various STEP trials

GCGR activation adds thermogenesis, fatty acid oxidation, and hepatic glucose production modulation beyond dual GIP+GLP-1 agonism

In this study, there was about a 7% placebo-adjusted reduction in bodyweight with the combination and about 2% and 4% with canagliflozin or phentermine alone, respectively [42]

However, this effect has been observed in one scientific study so far, so more tests are required to confirm it fully

Journal of Personality and Social Psychology, 36(8), pp