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Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling

Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons

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By simultaneously targeting glucose transporter type 1 (GLUT1), a glucose transporter critical for glucose uptake, and glutathione synthesis, which is intimately linked to NADPH production and reactive oxygen species scavenging, it may be possible to deplete NADPH levels and cause a buildup of reactive oxygen species