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Atul Malhotra, MD, a sleep medicine specialist at UC San Diego Health, and co-authors conducted two phase 3, double-blind, randomized controlled trials for tirzepatide in moderate-to-severe OSA patients with obesity who were and were not using CPAP

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Some of the authors have tried to define the evolution of NMS in five stages, with stage 5 being the most severe form characterized by extreme lead pipe rigidity, heart rate in the range of 130150 beats per min, systolic blood pressure ranging from 140 to 210 mmHg, diastolic blood pressure ranging from 100 to 110 mmHg, and body temperature in the range of 39C42C, accompanied by catatonia and coma.[] Diagnostic criteria Different diagnostic criteria have been proposed by different authors, including Addonizio criteria,[] Adityanjee criteria,[] Caroff and Manns criteria,[] Levensons criteria,[] Nirenberg criteria,[] and Popes criteria.[] Diagnostic and Statistical Manual (DSM), the fifth revision,[] has also provided the diagnostic criteria for NMS

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Strategies targeting metabolic vulnerabilities will not only eliminate backup systems to prevent ferroptosis [49] , but also receive considerable attention in cancer therapeutics [54]

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