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Altered Zn influx, efflux or buffering leads to intracellular zinc imbalance, which disrupts core molecular processes, including enzymatic activity, protein folding, signaling pathways and redox homeostasis

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This would mean oral dosing is only relevant for GI conditions

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Serotonin degeneration, associated with subsequent development of depressive symptoms, may be initiated by deposition of tau in the brainstem and exacerbated further by cortical A and the associated inflammatory response [125]

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