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This study develops a compound, JMF4073, inhibiting thymidylate (TMP) and cytidylate (CMP) kinases, aiming for a new therapy against TKI-resistant CML

[1] [2] Importantly, patients should not stop other medications such as ACE inhibitors, ARBs or diuretics without clinical advice, even during illness, as this requires individualised assessment

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Clinical trials show that when combined with lifestyle changes, users may lose 10-15% of their body weight

The proximal tubule is the primary target of injury and progression of kidney disease: role of the glomerulotubular junction