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Keller et al

No study has asked the broader question: do GLP-1s work against substance use disorders across the board, and can they reduce the serious harms of addiction, including overdose and drug-related death

Athletes looking to amplify this signal may benefit from timing injections approximately 30-60 minutes before training sessions, a practice analogous to pre-exercise peptide protocols used with BPC-157 and TB-500, though direct timing data for MOTS-c are not yet available in peer-reviewed literature

While tirzepatide does not directly cause thyroid dysfunction, weight loss and metabolic changes can sometimes unmask subclinical thyroid disease