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In addition, the observed differential 1-MNA steady-state levels following NNMT inhibition may reflect differential transcriptional regulation of cellular metabolic pathways across the various stages of 3T3-L1 differentiation;[38] for example, aldehyde oxidase (AOX)-mediated degradation of 1-MNA may be more pronounced in pre-adipocytes compared to adipocytes, thereby synergistically reducing 1-MNA levels to a greater extent in pre-adipocytes compared to adipocytes

[5] In the same 28-day study, DIO mice showed reduced body weight and fat mass gains alongside improved glucose tolerance and attenuated hepatic steatosis

Oral Protocols: Daily oral doses of 1, 5, 10, 20, and 30 mg were evaluated over 12 weeks

These include: Anaphylaxis : A severe, life-threatening allergic reaction that needs immediate help

There is no validated lab marker for NNMT inhibition outside research labs