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Clinically used iron chelators such as DFO and DFP, initially developed for the treatment of iron overload in -thalassemia and hemochromatosis, have been shown to mitigate tissue injury by inhibiting Fenton reaction-driven lipid peroxidation (409, 410)

they can happen with any form of rapid weight loss, regardless of the method

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Moreover, given the high plasma concentrations of endogenous albumin (40 mg/mL) 1 , the competitive pressure on the albumin binding site of FcRn is substantial 11