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The activation occurs via trans -phosphorylation of two catalytic tyrosines (Y1234 and Y1235) located in the kinase domain, followed by the subsequent auto-phosphorylation of the two docking tyrosines (Y1349 and Y1356) in the C-terminal tail

However, two critical physiochemical properties hindered drug development: 1) a lack of metabolic stability resulting in short circulating half-lives (eg

It crosses the blood-brain barrier and is involved in the production of energy within brain cells

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3 Researchers in both studies collected autoantibodies from the blood of long Covid volunteers and infused them into healthy mice, where the mice subsequently developed neurological features closely mimicking those seen in long Covid patients