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In vitro investigations demonstrated that LRE administration decreased H 2 O 2 -induced cytotoxicity in microglial cells, hence augmenting their antioxidant defenses

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10.3389/fnagi.2014.00216 196 RadhakrishnanJ.KennedyB

As the impairment of cutaneous sympathetic nerves is more remarkable in the extremities than that in the thorax with PD progression 45 , the lack of -synuclein fibrils in the legs is likely to represent the loss of -synuclein fibril-bearing sympathetic nerves

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