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Thats because it doesnt specifically work on just one type of hormone receptor

By targeting the intestine, PAS-LAR can cause or exacerbate diabetes mellitus by strongly inhibiting GLP-1 or GIP secretion

The medication is one tool

30 These clinical findings are supported by similar findings in basic science studies

Potential Negative Effects on Mental Health While the potential benefits are encouraging, its crucial to acknowledge the potential negative impacts of GLP-1 inhibitors on mental health: Increased Anxiety and Agitation: Paradoxically, while some studies suggest anxiety reduction, others have reported instances of increased anxiety, restlessness, and agitation in individuals taking GLP-1 agonists