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2D and 3D images were assessed to determine interactions between valine (VAL), tyrosine (TYR), tryptophan (TRP), threonine (THR), serine (SER), proline (PRO), phenylalanine (PHE), isoleucine (ILE), histidine (HIS), glycine (GLY), glutamine (GLN), glutamic acid (GLU), cysteine (CYS), and aspartic acid (CYS) residues and ligand residue (ALA)

c , Top, volcano plot showing relative fold change (log 2 ) in ER-metabolite abundance versus log 10 (P value) from ER-tag HEK293T cells treated with antimycin compared to untreated

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