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548 A subsequent clinical trial was conducted in melanoma patients with sequential administration of nivolumab and ipilimumab as well as the reverse sequence, and demonstrated that nivolumab followed by ipilimumab have a lower toxicity and similar clinical benefits with co-administration of nivolumab and ipilimumab

doi: 10.1016/j.ejphar.2018.10.053 183 TecilazichFDinhTPradhan-NabzdykLLealETellecheaAKafanasAet al

Generic makers may also face claims, though preemption rules limit some cases

Only 11.2% of participants discontinued due to side effects, meaning nearly 9 out of 10 people found it tolerable enough to continue