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See the AAAaAI review, a related PubMed case series and an FDA pharmacovigilance memo for more detail
In pernicious anemia, holotranscobalamin decreases whereas in dietary deficiency, holotranscobalamin will remain relatively stable while total serum B12 decreases
It changes how the body stores and metabolizes fat at a hormonal level
Another pilot study in 2024 involved 12 women with interstitial cystitis (a chronic bladder pain syndrome) who received BPC-157 injections directly into the bladder wall
This shows how important cyanocobalamin is in treating patients
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