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J Allergy Clin Immunol 153(2):AB67

The first month on a GLP-1 is incredibly important, not because you can mess things up, but because this is when the medication creates a powerful window of opportunity, explains Holly Wyatt, MD, a weight loss expert and author of Losing the Weight Loss Meds

From a downstream signalling standpoint, the semaglutide vs retatrutide divergence becomes even more pronounced when examining intracellular cascades

dose escalation may take up to 8 weeks: Week 1: Inject 0.6 mg subcutaneously once a day Week 2: Inject 1.2 mg subcutaneously once a day Week 3: Inject 1.8 mg subcutaneously once a day Week 4: Inject 2.4 mg subcutaneously once a day Week 5: Inject 3 mg subcutaneously once a day Maintenance dose : 2.4 or 3 mg subcutaneously once a day If maintenance dose is not tolerated, discontinuation is recommended