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Allergy warning: Contains soy

There are a whole bunch of other fitness measures in the paper: VO2 max tests, leg strength tests, body composition tests to measure muscle mass in the arms and legs

[1] [4] When to seek medical attention: Contact your healthcare provider immediately if you experience: Severe or persistent vomiting, signs of dehydration (dizziness, decreased urination) Severe abdominal pain, especially if radiating to your back (may indicate pancreatitis) Right upper abdominal pain, fever, or yellowing of skin/eyes (possible gallbladder disease) Decreased urine output or swelling (potential kidney problems) Neck mass, hoarseness, or difficulty swallowing (thyroid tumor warning signs) Severe allergic reactions including swelling of face/lips/tongue or difficulty breathing Visual changes (especially in patients with diabetic retinopathy) Symptoms of hypoglycemia (if taking insulin or sulfonylureas) Persistent nausea lasting beyond the first month or significantly impacting nutritional intake also warrants clinical evaluation

Medication is included at each tier

Male, 18-week-old C57BL/6J mice, maintained on a 60% high-fat diet (HFD