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Modulation of DNA methylation and gene expression in rodent cortical neuroplasticity pathways exerts rapid antidepressant-like effects

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In patients with established cardiovascular disease people who have already had a heart attack, stroke or coronary or peripheral artery disease semaglutide is now FDA-approved to reduce the risk of another heart attack or stroke or death from heart disease

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Patients achieving satisfactory results (5% or more weight loss with manageable side effects) on a low-cost generic liraglutide regimen may not benefit from the added expense and uncertainty of a newly approved drug