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Furthermore, the tauopathy model THY-Tau22 has phosphorylated tau expression correlated with hippocampal dysfunction and anxiety-like phenotypes (Schindowski et al., 2006)

This allows the stomach and gut to acclimate to the medication

After getting a B12 shot, you should watch out for these symptoms and see a doctor if you have: Strong pain where you got the shot Some stomach upset Feeling swollen Skin feeling itchy for a while In really rare cases, there might be more serious risks like: A severe allergic reaction called anaphylaxis Fluid build-up in the lungs Heart problems Blood clots in the bodys blood vessels A type of blood cancer, called polycythemia vera

Regulatory authorization for new drug for first indication, defined as Novel Drug Approval by FDA, and Marketing Authorization for New Active Substance by EMA.