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Ozempic and other GLP-1 receptor agonists dampen mesolimbic dopamine signaling, reducing reward salience and drug reinforcement across addictions
But when total weight loss exceeds 20%, as it does in many GLP-1/GIP patients, that 25% lean mass fraction represents a significant absolute deficit in muscle tissue
Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
In the exam room, Jane and I ultimately decided to try an older medication, metformin, for now to help with weight loss alongside other lifestyle changes
"Noom defines a microdose of GLP-1 as a fraction 25% or less of the typically prescribed maintenance dose
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