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The large 2025 meta-analysis quantified this as approximately 63% higher gastrointestinal adverse event rates compared with placebo, and gallbladder disorders were about 26% higher

However, it is also important to note that these findings demonstrate associations rather than cause and effect.

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In the 12-week extension phase, age averaged about 49 across the 4 study arms, slightly more than half of participants were women, and 47 (73%) were Hispanic