Most studies used a placebo as the control treatment, though a few compared GLP-1RAs with other medications or behavioral therapies
This ongoing surveillance is essential for detecting rare or previously unrecognised side effects that may not have been apparent during clinical trials
Furthermore, Methylcobalamin has been used to enhance cognitive function in elderly patients, providing a potential treatment option for age-related cognitive decline

References Ian J Neeland, Jennifer Linge, Andreas L Birkenfeld, 2024, Changes in lean body mass with glucagon-like peptide-1-based therapies and mitigation strategies pubmed.ncbi.nlm.nih.gov/38937282/ Allison B Reiss, Shelly Gulkarov, Raymond Lau, Stanislaw P Klek , Ankita Srivastava, Heather A Renna, Joshua De Leon, 2025, Weight Reduction with GLP-1 Agonists and Paths for Discontinuation While Maintaining Weight Loss Todd Miller, Stephanie Mull, Alan Albert Aragon, James Krieger, Brad Jon Schoenfeld, 2018, Resistance Training Combined With Diet Decreases Body Fat While Preserving Lean Mass Independent of Resting Metabolic Rate: A Randomized Trial Guidepoint Qsight, 2025, GLP-1 Medications Fuel Growth in Medical Aesthetics, with Weight Loss Accounting for 11% of Non-Surgical Spending in 2024 Tatiana Bido, 2024, New Report Tracks GLP-1s Impact on Plastic Surgery and Beauty Spending During Election Year Val Brickates Kennedy, 2024, Survey finds GLP-1 users more inclined to get aesthetic procedures AAFPRS Reveals New Statistics and Trends in Facial Plastic Surgery, 2025 Jessica Weiser, MD Ready to discover how Sofwave can transform your aesthetic practice

The dosing schedule can vary depending on individual needs, response to the medication, and healthcare provider recommendations