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The peptide's development focused on enhancing hydrophobicity, decreasing hydrogen bonding potential, and increasing metabolic stability, resulting in a compound with an exceptionally long plasma half-life of approximately 335 minutes

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10.1523/JNEUROSCI.3140-09.2010 J

A further increase by 39.8% in obesity-related DALYs and by 42.7% in obesity-related mortality is expected from 2020 to 2030 1

Key takeaway: Retatrutide delivers 24.2% weight loss (versus 14.9% for Wegovy and 20.9% for Zepbound) while maintaining a side effect profile thats actually better than Wegovy in several categories