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The amygdala hyperactivation, excessive sympathetic nervous system arousal, and impaired fear extinction that characterize anxiety disorders respond to different peptide targets than the anhedonia, BDNF deficits, and hippocampal atrophy more central to depression

This combination of reduced calorie burn and increased hunger makes Hashimoto's a genuine physiological barrier to weight loss, not simply a matter of willpower

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The broad mechanism of action for nitrofurantoin is likely responsible for the low development of resistance to its effects, as it affects many different processes important to the bacterial cell