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Free radical generation and lipid peroxidation has previously been associated with radiation-induced cardiotoxicity [86, 87], and recently, ferroptosis has been observed to contribute to radiation-induced atherosclerosis progression [45]

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213 More recent clinical trials have added to the evidence that omega-3 fatty acids have important benefits in CKD patients requiring hemodialysis

Because cuproptosis preferentially targets cells with high oxidative phosphorylation (OXPHOS) dependency, whereas glycolytic tumors remain relatively resistant, it exposes a distinct metabolic vulnerability in cancer and presents unique therapeutic opportunities 165,166

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