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70 Over the past 1 to 2 years, a growing number of global pharmaceutical companies has shown interest in amylin therapeutics, reflecting broader recognition of their potential to exceed the metabolic efficacy of current GLP-1based treatments

In the Swedish population, the inherited form of TTR amyloid accumulation is typically asymptomatic until middle age or later, indicating that age-related changes may contribute to disease onset

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Diabetes 60 , 31483153 (2011)

GI disorders were the most common AEs in the semaglutide groups in these studies, including nausea (14% to 58% in the semaglutide groups versus 5% to 22% in the placebo groups) and diarrhea (14% to 36% in the semaglutide groups versus 7% to 22% in the placebo groups)