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The histopathology of cirrhosis shows extensive necrosis of hepatocytes, nodular regeneration of residual hepatocytes, connective tissue hyperplasia, and fibrous septum formation, resulting in the destruction of the liver lobule structure and formation of pseudolobules ( The anti-inflammatory effect of caffeine varies with the treatment protocols and doses ( In the early stage of liver cirrhosis, there are no obvious symptoms due to the strong liver compensatory function, while in the later stage, liver function damage and portal hypertension are the main manifestations, and multiple systems are involved

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Transdermal delivery of GLP-1 medications faces significant challenges due to the large molecular size of GLP-1 analogs and the skin's natural barrier function