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Similarly, a recently approved antidiabetic agent of the same drug family, semaglutide, has been assessed in a double-blind phase 2 RCT in 320 patients with NASH without DM2, given subcutaneously once daily, at various doses, for 72 weeks (NCT02970942)

Furthermore, we confirmed GLP-1MK-801-mediated target engagement with NMDA receptors in GLP-1-receptor-positive neurons in the arcuate nucleus using electrophysiological recordings of isolated NMDA receptor currents

DivellaRDe PalmaGTufaroAPelagioGGadaleta-CaldarolaGBringiottiRet al (2021)

The combination of increased gastric pressure from gas accumulation and delayed emptying can worsen acid reflux dramatically

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