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Published cases overwhelmingly involve the highest available doses: 2.4 mg subcutaneous semaglutide weekly or 15 mg tirzepatide weekly

Effect of semaglutide 2.4 mg once weekly on 10-year type 2 diabetes risk in adults with overweight or obesity

If the injection has been given into muscle (intramuscular) rather than subcutaneous tissue, patients may experience more discomfort at the injection site, potentially faster absorption, and possibly more pronounced side effects

However, consistently hitting muscle due to poor technique could lead to irregular absorption patterns and suboptimal results over time

If more than five days have passed, skip the missed dose and take your next injection on the regularly scheduled day, ensuring at least 48 hours between doses