semaglutide phase 3 In an interim analysis of a trial involving 800 patients with metabolic dysfunction–associated steatohepatitis, once-weekly improved liver histologic results at 72 weeks. Full ESSENCE trial results and Research Summary Novo Nordisk Announces Positive Phase

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PPIs should be used at the lowest effective dose for the shortest duration necessary, as long-term use has been associated with (though not proven to cause) potential effects including nutrient malabsorption, increased infection risk, and bone health concerns

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Landmark trials include STEP (semaglutide for weight management, NEJM 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)