glp-1 data RA prescription trends: January 2018 – September 2025 Graph demonstrating change in weight

One area that has attracted academic discussion, press coverage, and significant biotechnology/pharma R&D investment is concern about undesirable, collateral skeletal muscle mass (SMM) loss, and presumably by extension, loss of strength and function in people taking GLP-1 medications

Why site rotation matters Injecting in the same spot repeatedly causes lipohypertrophy, which is a buildup of fatty tissue under the skin at the injection site

Once you add bacteriostatic water and reconstitute it, that same peptide has 4 to 6 weeks of useful life in the refrigerator

Puigserver, P

Current pharmacy coverage does not include GLP-1s for weight loss, unless your group has elected the benefit, for the many of the reasons outlined in the study