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While their direct antitumor effects remain speculative and mechanistically unclear, the indirect benefits are compelling

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70 Interestingly, GLP-1 agonists have been shown to augment the expression of Nrf2 when providing cytoprotective actions in cardiomyocytes 71 as well as pancreatic cells

The documented efficacy in diabetes management and the considerable cardiovascular advantages associated with particular GLP-1 agonists are two key drivers moving this industry ahead

The 1-year mean proportion of days covered was 77% (SD 30) and the 1-year median proportion of days covered was 97% (IQR 55100)