Despite their promise, the hydrophobic nature of certain carriers may lead to premature drug release, which can be mitigated by PEG modification or hydrophilic coatings [131]
As two negative regulators of p53, MDM2 and MDMX facilitate ferroptosis with or without p53, most likely by altering the lipid profile of cells (Venkatesh et al., 2020), which is confirmed by evidence that with the treatment of MDM2 inhibitor nutlin-3, p53 expression increases and leads to the suppression of X c system inhibitor-induced ferroptosis in HT-1080 cells (Tarangelo et al., 2018)
Cell Transplant 21(11):24412454
Comparing the Two: - Efficacy : Both Alpha Arbutin and Hydroquinone are effective skin-lightening agents, but Hydroquinone's potency often leads to quicker results, while Alpha Arbutin takes a more gradual approach
Corrigendum to Thapsigargin triggers cardiac contractile dysfunction via NADPH oxidase-mediated mitochondrial dysfunction: Role of Akt dephosphorylation [Free Radic
