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The central 5-azabenzimidazole group of LSN3318839 is lifted by the base of the binding pocket (Y145 1.40b and D198 2.68b ) through stacking with Y145 1.40b , cation stacking with K202 2.72b , and an aromatic hydrogen bond with D198 2.68b

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Activation of GLP-1R signaling promotes M2-like macrophage phenotype while inhibiting M1-like macrophages across various models

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In endotoxin-infused mice, free serum choline levels dropped by 49% at low endotoxin administration but increased by 98% within 48 hours after high endotoxin exposure (1 mg/kg)

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