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The activation of ER by E2 can occur through increased concentrations of cAMP, enhancing ER transcription

[PMC free article: PMC4552085] [PubMed: 25985364] 147

They could probably have a facelift, necklift, or other surgical procedure, but may not be ready to undergo surgery for whatever reason

HER2 overexpressing and triple negative breast cancer xenografts implanted in LDLR-/- mice models have increased expression of LDLR when exposing the mice for excessive circulating LDL-cholesterol [59]