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expect minimal GI effects | | 58 | **2mg** | Appetite suppression becomes noticeable | | 912 | **4mg** | Most users experience meaningful weight loss | | 1316 | **6mg** | Escalate only if tolerating 4mg well | | 1720 | **8mg** | Phase 2 trial's mid-high dose | | 21+ | **12mg** | Maximum studied dose

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This significant discrepancy between physiological requirements and therapeutic doses highlights the need for a deeper understanding of B12 absorption dynamics, rather than focusing solely on intake quantity