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Guanylate Cyclase-C Agonists Examples: Linaclotide, Plecanatide Mechanism: cGMP activates CFTR channels intestinal fluid secretion accelerate transit Uses: Chronic constipation, IBS-C Adverse Effects: Diarrhea, abdominal pain Bulk-forming safest, long-term use Osmotic acute or hepatic encephalopathy (lactulose) Stimulants short-term only Stool softeners post-surgery, hemorrhoids Lubricants avoid long-term Chloride channel activators & GC-C agonists newer agents for chronic constipation Mnemonic for Laxatives: BOSS-LC B Bulk-forming O Osmotic S Stimulant S Stool softeners L Lubricant C Chloride channel activators / cGMP agonists To view or add a comment, sign in More Relevant Posts Common medications cause nutrient deficiencies (and what to monitor) Many widely used drugs can reduce absorption or increase urinary losses of key vitamins/mineralsespecially with chronic use, higher doses, older age, limited intake, GI disease, or after bariatric surgery

[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Park S.-Y., Dae Kim Y., Seo Kim M., Kim K.-T., Yeon Kim J

GLP-1 receptor agonists were originally developed to treat type 2 diabetes

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