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While tirzepatide is not significantly metabolised by cytochrome P450 enzymes, it does delay gastric emptying, which can alter the absorption and exposure of some oral medications
[3] [4] The MHRA-approved product information for these medications clearly lists diarrhoea as a very common side effect, alongside nausea, vomiting, and constipation
Long-term plan: agree on duration
This might seem counterintuitive, but evolutionarily, it makes a lot of sense