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PE-22-28 Safety Considerations# PE-22-28's safety profile is less burdened by mechanism-specific concerns: TREK-1 channels are expressed throughout the body (brain, heart, vasculature, gastrointestinal tract), so systemic TREK-1 blockade could theoretically affect cardiovascular function, pain sensation, and gastrointestinal motility
Most studies consist of small human pilot studies conducted in the 1980s and a large body of animal preclinical data arising after the fact
Its like discovering that the first responders at a local clinic are also trained to rebuild entire hospitals
