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It causes damage to the blood vessels in the retina and may result in vision loss

Diabetes Obes Metab 22(12):24872492 Sun L, Yuan Y, Li Y, Rao X (2023) Effect of liraglutide on atherosclerosis in patients with impaired glucose tolerance: A double-blind, randomized controlled clinical trial

Insulin resistance alters renal tubular function, reducing urinary pH and citrate excretion (citrate normally inhibits stone formation) whilst increasing calcium excretion

Even under ideal conditions, oral supplements typically have an absorption rate of only 50% or less

Current GLP-1RA treatments will also likely retain their patents into the 2030s, reducing competition and preventing consumers from driving down prices