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Flavonoids increase the serum levels of FSH, and sharply decrease the serum levels of LH, testosterone and insulin in the PCOS-insulin resistant rats via partly inhibiting the activation of JAK2/STAT3 pathway, partially up-regulating the IL-6 expression and down-regulating the suppressor of cytokine signalling 3 (SOCS3) expression in ovaries of PCOS rats (106)

Lipovac et al

Genesis 63 (3), e70017

The treatment, which operates by targeting glucagon-like peptide-1 (GLP-1) receptors, falls within a class of drugs that are designed to affect the bodys insulin production and blood sugar levels