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Trends Pharmacol Sci 2018;39:36786.PubMed 45

[29] Although similarly effective as other antibiotics, prophylactic nitrofurantoin showed an increased risk of adverse effects compared to other antibiotics (risk ratios = 2.17 to 2.24)

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A longitudinal study published in 2026 found that baseline microbiome composition predicted glycemic response to semaglutide even in the absence of significant changes in microbiome diversity during treatment consistent with the hypothesis that response determinants are partly established before drug initiation (Dinkov & Pendicheva-Duhlenska, 2026)