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Early case series and open-label studies support feasibility and biological plausibility, whereas randomized trials show mixed clinical signals, highlighting donor-dependent effects, protocol heterogeneity (preconditioning, route, dose/frequency), and the need for engraftment-aware endpoints [252,253,254,255]

Icariin attenuates vascular endothelial dysfunction by inhibiting inflammation through GPER/SIRT1/HMGB1 signaling pathway in type 1 diabetic rats